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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク SrnB-SrnC toxin-antitoxin system ： ウィキペディア英語版 SrnB-SrnC toxin-antitoxin system The SrnB-SrnC toxin-antitoxin system of the F plasmid is homologous to the hok/sok system of R1. Like the hok/sok system, it performs a post-segregational killing function, ensuring that all surviving daughter cells inherit the F plasmid. The system consists of ''srnB' '' mRNA which is relatively stable and codes for the toxic protein SrnB, ''srnB'' mRNA, a regulatory element and ''srnC'' mRNA, an antitoxin with complementarity to ''srnB''. ==Mechanism of regulation and toxicity== The suspected method of regulation has not been directly tested for this system, however due to the strong similarity between this system and the hok/sok system, a mechanism of regulation has been inferred based on the structure of the mRNA and the mechanism used to regulate hok expression. The gene system consists of a stretch coding for ''srnB' '', ''srnB'' and ''srnC'' mRNA. ''srnB'' completely overlaps ''srnB' '' and is partly overlapped by ''srnC''. It appears that translation of ''srnB' '' is dependent on translation of ''srnB'', so regulation of expression of the SrnB toxin can be achieved indirectly by regulating translation of ''srnB''. It is thought that the initial mRNA transcript of ''srnB' '' is translationally inactive, and in plasmid-containing cells it will slowly bind ''srnC'' mRNA and be cleaved, or it will be specifically cleaved on the 3' end and rapidly bind ''srnC'', which indirectly inhibits translation of ''srnB' '' by regulating translation of ''srnB'' and causing cleavage. In a plasmid free cell, ''srnC'' degrades rapidly and remaining ''srnB' '' mRNA is processed into translationally active 3'-truncated mRNA which yields the SrnB toxic protein, killing the cell. The mechanism by which SrnB causes toxicity is not known, however similarity between the SrnB toxin sequence and the hok toxin sequence suggests that they make have similar functions. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SrnB-SrnC toxin-antitoxin system」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.